There is very little known of him from records, and he tended not to sign his work. He is believed to be responsible for mainly religious art, but also painted portraits on commission. He sometime painted from classical sources, often setting the figures in modern-dress, or a contemporary domestic setting. In his lifetime he was successful; he had a large workshop, his work was sold internationally and he was especially popular in Spain.
Benson became popular as a source for pastiche with 19th-century painters, who are sometimes known as the "followers of Benson". In particular his many variations of the Magdalen and Sibilla Persica were further copied and became popular with contemporary buyers. Many have retained their relative value and held in the National Gallery, London and command high prices at Sotheby's.